TNF--a antagonists and sarcoidosis

Efficacy and safety of TNF antagonists in sarcoidosis: data from the Spanish registry of biologics BIOBADASER and a systematic review.

OBJECTIVE To evaluate the safety, efficacy, and effectiveness of TNF antagonists in patients with sarcoidosis. METHODS A descriptive study of a case series registered in BIOBADASER and a systematic review was performed. The search strategy of articles published between 1998 and July 2011 in Medline, Embase, and the Cochrane Library included synonyms of sarcoidosis and synonyms of TNF antagoni...

Effective use of TNF antagonists

Tumor necrosis factor (TNF) antagonists are biologic response modifiers that have significantly improved functional outcomes in patients with rheumatoid arthritis (RA). RA is a progressive disease in which structural joint damage can continue to develop even in the face of symptomatic relief. Before the introduction of biologic agents, the management of RA involved the use of disease-modifying ...

Eosinophilia during psoriasis treatment with TNF antagonists.

Association of the TNF-a G-308A polymorphism with TNF-inhibitor response in sarcoidosis

Responsiveness to tumour necrosis factor (TNF) inhibitors has been associated with the TNF-a G-308A polymorphism in rheumatoid arthritis. The aim of this study was to examine the association between the presence of this polymorphism and the response to TNF inhibitors in patients with refractory sarcoidosis. Patients (n5111) who started TNF-inhibitor treatment (76 infliximab, 35 adalimumab) were...

The Comparative Safety and Effectiveness of TNF-Antagonists

OBJECTIVE: To describe the current knowledge on safety and effectiveness of the tumor necrosis factor (TNF)-α antagonists and identify current knowledge/evidence gaps for study by the Agency for Healthcare Research and Quality (AHRQ) Effective Health Care Program. BACKGROUND: Evidence-based Practice Centers (EPCs) and the Developing Evidence to Inform Decisions about Effectiveness (DEcIDE) netw...